Chloromethyltrimethylsilane is a common silylating agent in organic synthesis. Trimethylsilyl groups protect alcohols and other reactive functional groups during complex reaction sequences in organic molecules. Its efficiency and gentle removal of the protecting group make this reagent popular for further synthetic transformations. It is used to make silyl ethers, which are useful intermediates in pharmaceutical, agrochemical, and organic compound synthesis. Due to its reactivity and moisture sensitivity, handle this reagent carefully.

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